Examination of the drug that not only prevented from getting type 1 diabetes, but changing condition if you already hold.

Verapamil is used for treating high blood pressure, irregular heartbeat, and some types of headaches.

It is approved for some of these purposes over 30 years. Shalev_lab-11

Verapamil has dangerous interactions with other drugs.

The side effects such as nausea and swollen feet are rarely life-threatening and generally a better alternative than to having diabetes.

As a history of long-term use should shorten clinical trial processes and improve chances of regulatory approval.

The discovery by Dr. Anath Shalev that verapamil lowers protein TXNIP in pancreatic .

Then, at the University of Wisconsin-Madison, Shalev began a quest to find the gene that reacted most strongly to the excessive levels of glucose.

It turns out that the gene was TXNIP. High level TXNIP showed that pancreatic insulin-producing beta islet cells alive.

He began to suspect that TXNIP may be the key to the fight against diabetes and tests in rats, mice, isolated from the people they lent weight to her theory.

Verapamil may prevent diabetes, and even reverse the disease laboratory tests with mice and reduce TXNIP, suggesting that it may have beneficial effects in humans.

Shalev found that TXNIP may stimulate its own expression.tumblr_static_tumblr_static_465g385sdm804gcocwo8scs4c_1280

He wrote that the levels of TXNIP grow over time, not only as a result of elevated blood glucose levels or stress, but also as part of a vicious circle in which increased level of TXNIP leads to more TXNIP expression and thereby increase the associated detrimental effects on beta-cell biology , including oxidative stress, inflammation, and death of disease progression.

Testing will include 52 newly diagnosed patients with diabetes, half of these whom will be put on verapamil and half a placebo.

All patients will continue to receive insulin therapy. Lowering TXNIP, even in the context of worst diabetes, we have a positive impact, “says Shalev.

There is currently no treatment available that targets diabetes in this way.

Meanwhile Shalev is starting to work on producing molecules with more targeted and efficient versions of verapamil’s effect on TXNIP.